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Members of the group
Curriculum Vitae of the group
Contacts with the Industry
Laboratory of Pharmacochemistry |
| Curriculum Vitae of the group |
Subject & Research Areas |
| 1- Structure-activity relationships of antitumor Acetogenins (ACG): interaction of tetrahydrofuranic g-lactones on Complex-I of the mitochondrial respiratory chain. |
| *Isolation, structural elucidation and semisynthetic ACG |
| *Study of the selective inhibition of ACG on mitochondrial (complex I) dehydrogenase NADH enzyme. |
| *Application to the study of mitochondrial diseases: Parkinson, Huntington’s chorea. |
| 2- Synthesis of isoquinolines and indenopiridas dopamine. |
| *Synthesis of benzyl tetrahydroisoquinoline and hexahidroindenopiridines. |
| *Asymmetric synthesis of benzyltetrahydroisoquinolines. |
| *Dopaminergic activity of isoquinolines. Inhibition of cell cycle. |
| 3- Projects with pharmaceutical companies: |
| ·Servier Laboratories |
| ·Merck, Sharp & Dohme |