Pharmacochemistry Laboratory

  Teaching & Collaborations
  The teaching given in the Pharmacy Degree is specified below:

  a) Pharmacognosy. Study of bioactive secondary metabolites (BSM), medicines of natural origin obtained from raw materials (RM) of plants, animals, microorganisms and of marine origin.

  * A total of 90 hours / year are taught to 3rd year students of the Pharmacy Degree at the University of Valencia, Spain.

  * The teaching consists of:
   - Theoretical classes,
   - Laboratory Practical Classes,
   - Seminars on specific topics prepared by the students, and
   - Problem solving tutorials: extraction, biosynthesis and NMR.

  b) Subject content #

  * Information about BSM based on its pharmacological activity (Chapters 6 to 18). In the initial chapters (Chapters 1 to 5) the generalities on the BSMs are studied: biological origin, extraction methods from the PM, biogenetic origin and structural determination by NMR.

  * The content of the subject is detailed below:

Chapter Index

Section I. Introduction
        Chapter 1.-     Bioactive Secondary Metabolites (BSM)
        Chapter 2.-     Isolation of MSA: extraction and purification methods   
        Chapter 3.-     BSM biosynthesis: polyacetates, shikimates and isoprenoids
        Chapter 4.-     BSM biosynthesis: amino acid derivatives
        Chapter 5.-     Structural Determination of BSM using NMR

Section II. BSM used in the different systems
        Chapter 6.-     BSM that act in the Cardiovascular System   
        Chapter 7.-     BSM that act in the Digestive System
        Chapter 8.-     BSM Haemostatic and Plasma Substitutes
        Chapter 9.-     BSM Metabolism Modifiers
        Chapter 10.-     BSM that act in the Adrenergic System
        Chapter 11.-     BSM que actúan en el Sistema Adrenérgico
        Chapter 12.-     BSM Analgesics
        Chapter13     BSM that act in the Central Nervous System   
        Chapter 14.-     Cannabinoids

Section III. BSM in the treatment of infections, cancer, immunomodulators and antivirals
        Chapter 15.-     BSM Antimalarials
        Chapter 16.-     BSM Antibiotics
        Chapter 17.-     BSM Antitumoral
        Chapter 18.-     BSM Immunomodulators and Antivirals

# Pharmacognosy Manual
 On which the teaching given is based (Spanish and English versions):

  * Departamento de Química, Universidad Nacional de San Luis (Argentina)
  - Dr. Daniel ENRIZ y Dr. Fernando SUVIRE
  - Molecular modeling.
  * IRCOF, U. de Rouen y Laboratoire de Pharmacognosie, U. Paris-XI (Francia)
  - Dr. Xavier FRANCK y Dr. Bruno FIGADÈRE
  - Synthesis of bioactive compounds.
  * Laboratorio de Fisiología y Química Vegetal, Universidad de Ciencias y Artes de Chiapas, Tuxtla Gutiérrez (México)
  - Isolation of bioactive compounds.
  * Departamento de Q. Orgánica, Universidad Nacional de Tucumán (Argentina)
  - Dra. Adriana NESKE y Dra. Alicia BARDON
  - Isolation of bioactive compounds.
  * CERMN, Université de Caen (Francia)
  - Dr. Sylvain RAULT y Dra. Valérie COLLOT
  - Synthesis of bioactive compounds.
  * Departamento de Química, Universidad de Antioquia, Medellín (Colombia)
  - Dr. Jairo SAEZ y Dr. Gabriel J. ARANGO
  - Isolation and synthesis of bioactive compounds.

  * Departamento de Química, Universidad de Antioquia, Medellín (Colombia)
   - Dra. Mabel Loza
   - Departamento de Farmacología, Universidad de Santiago de Compostela

 Daniel (San Luis), María Jesús, Javier, Nuria, Bruno (Châtenay) and Diego
(Javier Parraga PhD – March 2015)