Laboratoire de Pharmacochimie

 
 
  Publications
 
Publications (2000-2020)
 
  1. Synthèse de molécules bioactives.
  2. Isolement des acétogénines et d’autres métabolites
  3. Livres et revues. Métabolites secondaires actifs.
  a) Synthèse de molécules bioactives. Benzopyranes prénylés, affinité pour les récepteurs nucléaires. Isoquinoléine dopaminergique.

 - Silva, A. G., Vila, L., Marques, P., Moreno, L., Loza, M., Sanz, M. J., Cortes, D., Castro, M. y Cabedo, N.
 1‑(2′-Bromobenzyl)-6,7-dihydroxy‑N‑methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D2 Dopamine Receptors
 Journal of Natural Products 2020, 83, 127−133

 - Bermejo, A., Collado, A., Barrachina, I., Marques, P.; El Aouad, N., Franck, X., Garibotto, F., Dacquet, C., Caignard, D.-H., Suvire, F., Enriz, R. D., Piqueras, L., Figadère, B., Sanz, M. J., Cabedo, N. y Cortes, D. 
 Polycerasoidol, a Natural Prenylated Benzopyran with a Dual PPARα/PPARγ Agonist Activity and Anti-inflammatory Effect
 Journal of Natural Products 2019, 82, 1802-1812.

 - Bermejo, A., Barrachina, I., El Aouad, N., Franck, X., Chahboune, N., Andreu, I., Figadère, B., Vila, L. Hennuyer, N., Staels, B., Dacquet, C., Caignard, D. H., Sanz, M. J., Cortes, D. y Cabedo, N.
 Synthesis of benzopyran derivatives as PPARα and/or PPARγ activators.
 Bioorganic & Medicinal Chemistry 2019, 27, 115162.   

 - El Aouad, N., Mechqoq, H., El Yaagoubi, M., Masanda, F. y Cortes, D.
 Semisynthesis of New Antibacterial Triterpenoids Derivatives from the Natural α-Euphorbol
 Indian Journal of Natural Sciences 2019, 9, 17335-17342.

 - Sofiane, I., Seridi, R., Cortes, D. y Cabedo, N.
 Phytochemical Composition and Evaluation of the Antioxidant Activity of the Ethanolic Extract of Calendula suffruticosa subsp. suffruticosa Vahl
 Pharmacognosy Journal 2018, 10, 64-70.

 - Enriz, R. D., Tosso, R. D., Andújar, S., Cabedo, N., Cortes, D., Nogueras, M., Cobo, J., Vargas, D. F. y Trilleras, J.
 Indole-substituted 2,4-diamino-5,8-dihydropyrido[2,3-d]pyrimidines from one-potprocess and evaluation of their ability to bind dopamine receptors.
  Tetrahedron 2018, 74, 7047-7057.

 - Parravicini, O., Bogado, M. L., Rojas, S., Angelina, E. L., Andújar, S. A.,Gutierrez, L. J., Cabedo, N., Sanz, M. J., López-Gresa, M. P., Cortes, D. y Enriz, R. D.
 Tetrahydroisoquinolines functionalized with carbamates as selective ligands of D2 Dopamine Receptor
  Journal of Molecular Modeling 2017, 23 (273), 1-14.

 - Párraga, J., Andujar, S., Rojas, S., Gutierrez, L. J., El Aouad, N., A., Sanz,M. J., Enriz, R. D., Cabedo, N. y Cortes, D.
 Dopaminergic isoquinolines with hexahydrocyclopenta[ij]-isoquinolines as D2-like selective ligands
 European Journal of Medicinal Chemistry 2016, 122, 27-42.

  - Párraga, J., Galán, A., Sanz, M. J., Cabedo, N. y Cortes, D
  Synthesis of hexahydrocyclopenta[ij]isoquinolines as a new class of dopaminergic agents
  European Journal of Medicinal Chemistry 2015, 90, 1001-106.
 
  - Angelina, E., Andujar, S., Moreno, L., Garibotto, F., Párraga, J., Peruchena, N., Cabedo, N., Villeco, M., Cortes, D., y Enriz, R. D.
  3-Chlorotyramine acting as ligand of the D2 dopamine receptor. Molecular modelling, synthesis and D2 receptor affinity.
  Molecular Informatics 2015, 34, 28-43.
 
  - Párraga, J., Moreno, L., Díaz, A., El Aouad, N., Galán, A., Sanz, M. J., Caignard, D. H., Figadère, B., Cabedo, N. y Cortes, D.
  Efficient synthesis of hexahydroindenopyridines and their potential asmelatoninergic ligands 
  European Journal of Medicinal Chemistry 2014, 86, 700-709.
 
  - Moreno, L., Berenguer, I., Díaz, A., Marín, P., Párraga, J., Caignard, D. H., Figadère, B., Cabedo, N. y Cortes, D.
  Synthesis of new melatoninergic hexahydroindenopyridines
  Bioorganic & Medicinal Chemistry Letters 2014, 24, 35343536.
 
  - Galán, A., Moreno, L., Párraga, J., Serrano, A., Sanz, M. J., Cortes, D. y Cabedo, N.
  Novel isoquinoline derivatives as antimicrobial agents
  Bioorganic & Medicinal Chemistry 2013, 21, 3221-3230.
 
  - Moreno, L., Cabedo, N., Ivorra, M. D., Sanz, M. J., López Castel, A., Álvarez, M. C. y Cortes, D.
  3,4-Dihydroxy- and 3,4-methylenedioxy- phenanthrene-type alkaloids with high selectivity for D2 dopamine receptor
  Bioorganic & Medicinal Chemistry Letters 2013, 23, 4824-4827.
 
  - Párraga, J., Cabedo, N., Andújar, S., Piqueras, L., Moreno, L., Galán, A., Angelina, E., Enriz, D. R., Ivorra, M. D., Sanz, y Cortes, D.
  2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2dopaminergic ligands
  European Journal of Medicinal Chemistry 2013, 68, 150-166.
 
  - Moreno, L., Cabedo, N., Boulangé, A., Párraga, J., Galán, A., Leleu, S., Sanz, M. J., Cortes, D. y Franck, X.
  Synthesis of pyrido[2,1-a]isoquinolin-4-ones and oxazino[2,3-a]isoquinolin-4-ones: New inhibitors of mitochondrial respiratory chain
  European Journal of Medicinal Chemistry 2013, 69, 69-76.

  - Moreno, L., Párraga. J., Galán, A., Cabedo, C., Primo, J. y Cortes, D.
  “Synthesis of new antimicrobial pyrrolo[2,1-a]isoquinoline-3-ones
  Bioorganic & Medicinal Chemistry 2012 20, 6589-6597.
 
  - Andujar, S. A., Tosso, R. D., Suvire, F. D., Angelina, E., Peruchena, N., Cabedo, N.,
Cortes, D. y Enriz, R. D.
  “Searching the Biologically Relevant Conformation of Dopamine: A Computational Approach”
  Journal of Chemical Information and Modeling 2012, 52, 99−112.
 
  - Andujar, S., Suvire, F., Berenguer, I., Cabedo, N., Marín, P., Moreno, L., Ivorra, M. D., Cortes, D. y Enriz, R.  D.
  “Tetrahydroisoquinolines acting as dopaminergic ligands. A molecular modeling study using MD simulations  and QM calculations”
  Journal of Molecular Modeling 2012, 18, 419–431.
 
  - Rejón-Orantes, J. C., González-Esquinca, A. R., Pérez de la Mora, M., Roldan, G. y
Cortes D.
  “Annomontine, an alkaloid isolated from Annona purpurea has anxiolytic-like effects in the elevated plus-maze”
  Planta Medica 2011 77, 322-327.
 
  - Berenguer, I., El Aouad, N., Andujar, S., Romero, V., Suvire, F., Freret, T. Bermejo, A., Ivorra, M. D., Enriz, R.D., Boulouard, M., Cabedo N. y Cortes, D.
  "Tetrahydroisoquinolines as Dopaminergic Ligands: 1-Butyl-7-chloro-6-hydroxy-tetrahydro- isoquinoline, a New Compound with Antidepressant-like Activity in Mice”
  Bioorganic & Medicinal Chemistry 2009 17, 4968-4980.
 
  - El Aouad, N., Berenguer, I., Romero, V., Marín, P., Serrano, A., Andujar, S., Suvire, F., Bermejo, A., Ivorra, M. D., Enriz, R. D., Cabedo, N. y Cortes, D.
  "Structure-Activity Relationship of dopaminergic halogenated 1-benzyltetrahydroisoquinoline derivatives”
  European Journal Medicinal Chemistry 2009 44, 4616-4621.
 
  - Camps, P., Duque, M. D., Vázquez, S., Naesens, L., De Clercq, E., Sureda, F. X.,
López-Querol, M., Camins, A., Pallàs, M., Prathalingam, S. R., Kelly, J. M., Romero, V.,
Ivorra, M. D. y Cortes, D.
  "Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs"
  Bioorganic & Medicinal Chemistry 2008 16, 9925-9936.
 
  - Sáez, A., Ramírez de Arellano, C., El Aouad, N., Rodríguez, S., Otalvaro, F., Cortes, D. y Sáez, J.
  “Semisynthetic roxburghin tetramethyl ether”
  Acta Crystallographica Section E 2008 64, 1305.
 
  - Cabedo, N., El Aouad, N., Berenguer, I., Zamora, M., Ramírez de Arellano, M. C.,
Suvire, F., Bermejo, A., Enriz, R. D. y Cortes, D.
  “Efficient synthesis and structural analysis of new dioxopiperazine isoquinolines”
  Tetrahedron 2006 61, 4408-4418.
 
  - Voisin, A. S., Bouillon, A., Berenguer, I., Lancelot, J.-C., Lesnard, A. y Rault, S.
  “Novel oxybispyridylboronic acids: synthesis and study of their reactivity in Suzuki-type cross-coupling reactions”
  Tetrahedron 2006 62, 11734-11739.
 
  - Andreu, I., Cabedo, N., Fabio, F., Cortes, D. y Rault, S.
  “Synthesis of new 8-arylisoquinoline derivatives by application of palladium-catalyzed Suzuki cross-coupling reactions”.
  Tetrahedron 2005 61, 8282-8287.
 
  - Granell, S., Andreu, I., Martí, D., Cavé, A., Aragón, R., Estornell, E., Cortes, D. y Zafra-Polo, M. C.
  “Bisbenzyltetrahydroisoquinolines, a new class of inhibitors of the mitochondrial respiratory chain complex I”
  Planta Medica 2004, 70, 266-268.
 
  - Suvire, F. D., Andreu, I., Bermejo, A., Zamora, M. A., Cortes, D. y Enriz, R. D.
  “Conformational study of N-alkyl-benzyltetrahydroisoquinolines alkaloid”.
  Journal of Molecular Structure (Teochem) 2003, 666-667, 196-204.
 
  - Suvire, F. D., Cabedo, N., Chagraoui, A., Zamora, M. A., Cortes, D. y Enriz, R. D.
  “Molecular recognition and binding mechanism of N-alkyl-benzyltetrahydroisoquinolines to the D1 dopamine receptor. A computational approach”.
  Journal of Molecular Structure (Teochem) 2003, 666-667, 446-454.
 
  - Andreu, I., Cabedo, N., Atassi, G., Pierré, A., Caignard, D. H., Renard, P., Cortes, D. y Bermejo, A.
  “An efficient method for the preparation of antitumoral a-keto-imines benzyldihydroisoquinolines by selective benzylic oxidation with C/Pd in acetonitrile”
  Tetrahedron Letters 2002, 43, 757-759.
 
  - Bermejo, A., Andreu, I., Suvire, F., Léonce, S., Caignard, D. H., Renard, P., Pierré, A., Enriz, R. D., Cortes, D. y Cabedo, N.
  “Syntheses and Antitumor Targeting G1 Phase of the Cell Cycle of Benzoyldihydroisoquinoline and Related 1-Substituted Isoquinolines”
  Journal of Medicinal Chemistry 2002, 45, 5058-5068.
 
  - Andreu, I., Cabedo, N., Torres, G., Chagraoui, A., Ramírez de Arellano, M. C., Gil, S., Bermejo, A., Valpuesta, M., Protais, P. y Cortes, D.
  “Syntheses of Dopaminergic 1-Cyclohexylmethyl-7,8-Dioxygenated Tetrahydro-isoquinolines by Selective Heterogeneous Tandem Hydrogenation”
  Tetrahedron 2002, 58, 10173-10179.
 
  - Cabedo, N., Andreu, I., Ramírez de Arellano, M. C., Chagraoui, A., Serrano, A.,
Bermejo, A., Protais, P. y Cortes, D.
  “Enantioselective Syntheses of Dopaminergic (R)- and (S) Benzyltetrahydr-oisoquinolines”
  Journal of Medicinal Chemistry 2001, 44, 1794-1801.
 
  - Andreu, I., Cortes, D., Protais, P., Cassels, B. K., Chagraoui, A. y Cabedo, N.
  “Preparation of Dopaminergic N-Alkyl-benzyltetrahydroisoquinolines using a ‘One-Pot’ Procedure in Acid Medium”
  Bioorganic & Medicinal Chemistry 2000, 8, 889-895.
 
  - Tur, R., Magraner, J., Catret, M., Elorriaga, M., Ivorra, M. D., D’Ocón, P., Bermejo, A.,
Cabedo, N., Cortes, D. y Anselmi, E.
  “Mechanism of vascular relaxation by thaligrisine: functional and binding assay”
  Life Sciences 2000, 67, 1535-1548.
 
  - Andreu, I, Cabedo, N., Tormo, J. R., Bermejo, A., Mello, R. y Cortes, D.
  “Synthesis of N-Diisopropyl Phosphoryl Benzyltetrahydroisoquinoline, a New Class of Mitochondrial Complex I and III Inhibitors”
  Bioorganic & Medicinal Chemistry Letters 2000, 10, 1491-1494.
 
 
   b) Isolement des Acétogénines et d’autres métabolites

  - Neske, A., Hidalgo, J. R., Cabedo, N y Cortes, D.
  Acetogenins from Annonaceae family. Their potential biological applications
  Phytochemistry 2020, 174, 112332.

- Hidalgo, J. R., Gilabert, M., Cabedo, N, Cortes, D. y Neske, A.
  Montanacin-L and montanacin-K two previously non-described acetogenins from Annona montana twigs and leaves.
  Phytochemistry Letters 2020, 38, 78-83.

  - Paes, M. M., Vega, M. R. G., Cortes, D. y Kanashiro, M. M.
  Potencial citotóxico das acetogeninas do género Annona.
  Revista Virtual de Química 2016, 4, 945-980.   

  - Paes, M. M., Vega, M. R. G., Cortes, D., Cabedo, N. y Kanashiro, M. M.
  Cytotoxic activities of acetogenins from Annona dioica Roots.
  International Journal of Sciences 2015, 4, 19-29.       

  - Cortes, D., Moreno, L., Párraga, J., Galán, A. y Cabedo, N.
  New Medicines inspirated in Annonaceae
  Revista Brasileira de Fruticultura 2014, 36, 22-31.   


  - De Pedro, N., Cautain, B., Melguizo, A., Cortes, D., Vicente, F., Genilloud, O., Tormo, J. R. y Peláez, F.
  Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I
  Journal of Bioenergetics and Biomembranes 2013, 45, 145-152.
 
  - Sebastianes, F. L. S., Cabedo, N., El Aouad, N., Valente, A. M. M. P., Lacava, P. T., Azevedo, J. L., Pizzirani-Kleiner, A. A. y Cortes, D.
  3-Hydroxypropinoic Acid as an Antibacterial Agent from Endophytic Fungi Diaporthe phaseolorum
  Current Microbiology 2012, 65, 622-632.
 
  - Barrachina, I., Royo, I., Baldón. H. A., Chahboune, N., Suvire, F., DePedro,N.,
Zafra-Polo, M. C., Bermejo, A., El Aouad, N., Cabedo, N., Sáez, J., Tormo, J. R.,
Enriz, R. D. y Cortes, D.
  “New Antitumoral Acetogenin “Guanacone type” Derivatives: Isolation and BioactivityMolecular Dynamics Simulation of Diacetyl-guanacone”
  Bioorganic & Medicinal Chemistry 2007 15, 4369-4381.
 
  - Ciavatta, M. L., López Gresa, M. P., Gavagnin, M., Romero, V., Melck, D., Manzo, E.,
  Guo, Y.-W., Van Soest, R. y Cimino, G.
  “Studies on puupehenone-metabolites of a Dysidea sp.: structure and biological activity”
  Tetrahedron 2007, 63, 1380-1384.
 
  - Chahboune, N., Barrachina, I., Royo, I., Romero, V., Sáez, J., Tormo, J. R., DePedro, N., Estornell., E., Zafra-Polo, M. C., Peláez, D. y Cortes, D. 
  “Guanaconetins, New Antitumoral Acetogenins, Mitochondrial Complex I and Tumor Cell Growth Inhibitors
  Bioorganic & Medicinal Chemistry 2006 14, 1089-1094.
 
  - Duval, R. A., Lewin, G., Peris, E., Chahboune, N., Garofano, A., Dröse, S., Cortes, D., Brandt, U. y Hocquemiller, R.
  “Heterocyclic Analogues of Squamocin as Inhibitors of mitochondrial Complex I. On the Role of the Terminal Lactone of Annonaceous Acetogenins”
  Biochemistry 2006 45, 2721-2728. 
 
  - Duval, R. A., Poupon, E., Romero, V., Peris, E., Lewin, G., Cortes, D., Brandt, U. y Hocquemiller, R.
  “Analogues of cytotoxic squamocin using reliable reactions: new insights into the reactivity and role of the α,β-unsaturated lactone of the annonaceous acetogenins”
  Tetrahedron 2006 62, 6248-6257.
 
  - Tormo, J. R., DePedro, N., Royo, I., Barrachina, I., Zafra-Polo, M. C., Cuadrillero, C., Hernández, P., Cortes, D. y F. Peláez.
  “In vitro Antitumor structure activity relationships of threo/trans/threo/trans/erythro bis- tetrahydrofuranic acetogenins: Correlations with their inhibition of mitochondrial complex I”.
  Oncology Research 2005, 15, 129-138.
 
  - Defretin, J., Gleye, C., Cortes, D. Franck, X., Hocquemiller, R. y Figadère, B.
  “Synthesis and Mitochondrial Complex I Activity of Annonaceous Trans and Cis Solamins Precursors”
  Letters in Organic Chemistry 2004, 1, 316-322.
 
  - Barrachina, I., Neske, A., Granell, S., Bermejo, A., Chahboune, N., El Aouad, N.,
Alvarez, O., Bardon, A. y Zafra-Polo, M. C.
  “Tucumanin, a β-hydroxy-γ-lactone bistetrahydrofuranic acetogenin from Annona cherimolia, is a potent inhibitor of mitochondrial complex I”
  Planta Medica 2004, 70, 866-868.
 
  - Tormo, J. R., Royo, I., Gallardo, T., Zafra-Polo, M. C., Hernández, P., Cortes, D.  
y Peláez, F.
  “In Vitro Antitumor SAR of threo/trans//threo mono-Tetrahydrofuranic Acetogenins: Correlations With Their Inhibition of Mitochondrial Complex I”.
  Oncology Research 2003, 14, 147-154.
 
  - Royo, I., DePedro, N., Estornell, E., Cortes, D., Peláez, F. y Tormo, J. R.     
  “In Vitro Antitumor SAR of threo/cis/threo/cis/erythro bis-THF Acetogenins: Correlations With Their Inhibition of Mitochondrial Complex I”
  Oncology Research 2003, 13, 521-528.
 
  - Tormo, J. R., Gallardo, T., Peris, E., Bermejo, A., Cabedo, N., Estornell., E.,
Zafra-Polo, M. C. y Cortes, D.
  “Inhibitory Effects on Mitochondrial Complex I of Semisynthetic Mono-Tetrahydrofuran Acetogenin Derivatives”.
  Bioorganic & Medicinal Chemistry Letters 2003, 13, 4101-4105.
 
  - Peris, E., Cavé, A., Estornell, E., Zafra-Polo, M. C., Figadère, B., Cortes, D. y Bermejo, A.
  “Semisynthesis of New Tetrahydrofuranic alkyl ester and furano-pyrone derivatives as Inhibitors of the Mitochondrial Complex I”
  Tetrahedron 2002, 58, 1335-1342.
 
  - González-Coloma, A., Guadaño, A., De Inés, C., Martínez-Díaz, R. y Cortes, D.
  “Selective Action of Acetogenin Mitochondrial Complex I Inhibitors”
  Z. Naturforsch. 2002, 57c, 1028-1034.
 
  - Tormo, J. R., Estornell, E., Gallardo, T., González, M. C., Cavé, Ad., Granell, S.
  “γ-Lactone-Functionalized Antitumoral Acetogenins are the Most Potent Inhibitors of Mitochondrial Complex I”
  Bioorganic & Medicinal Chemistry Letters 2001, 11, 681-684.
 
  - Granados, H., Sáez, J., Saldarriaga, N., Moreno, M. E., Peláez, C., Brun, N., Arbeláez, C. y Cortes, D.
  “In Vitro Insecticidal Activity of the Annona aff. spraguei Seeds (Annonaceae) on two Biological Model of Diptera order: Drosophila melanogaster and Aedes aegypti
  Afinidad 2001, 58, 44-48.
 
  - López-Lázaro, M., Martín-Cordero, C., Bermejo, A., Cortes, D. y Ayuso, M. J.
  “Cytotoxic Compounds from Annonaceus Species as DNA Topoisomerase I Poisons”
  Anticancer Research 2001, 21, 3493-3498.
 
  - Tormo, J. R., Zafra-Polo, M. C., Serrano, A., Estornell, E. y Cortes, D.
  “Epoxy-acetogenins and other polyketide epoxy derivatives as inhibitors of the mitochondrial respiratory chain complex I”
  Planta Medica 2000, 66, 318-323.
 
  - Tormo, J. R. y Estornell, E.
  “New Evidence for the Multiplicity of Ubiquinone- and Inhibitor-Binding Sites in the Mitochondrial Complex I”
  Archives of Biochemistry and Biophysics 2000, 381, 241-246.
 
  - Guadaño, A., Gutiérrez, C., de la Peña, E., Cortes, D. y González-Coloma, A.
  “Insecticidal and mutagenic evaluation of two Annonaceous acetogenins”
  Journal of Natural Products 2000, 63, 773-776.
 
  - Peris, E., Estornell, E., Cabedo, N., Cortes, D. y Bermejo, A.
  “3-Acetylaltholactone and related styryl-lactones, mitochondrial respiratory chain inhibitors”
  Phytochemistry 2000, 54, 311-315.
 
  - Gallardo, T., Zafra-Polo, M. C., Tormo, J. R., González, M. C., Franck, X., Estornell, E. y Cortes, D.
  “Semisynthesis of Antitumoral Acetogenins: SAR of Functionalized Alkyl-Chain Bis-Tetrahydrofuranic Acetogenins, Specific Inhibitors of Mitochondrial Complex I”
  Journal of Medicinal Chemistry 2000, 43, 4793-4800.
 
 
   c) Livres et revues. Métabolites Secondaires Actifs
 
  - Cortes, D., Moreno, L., Párraga, J., Galán, A. y Cabedo, N.
  New Medicines inspirated in Annonaceae
  Revista Brasileira de Fruticultura 2014, 36, 22-31.
 
  - Cabedo, N., Moreno, L., López, S., Marín, P., Párraga, J. y Cortes, D. 
  Las Annonáceas: Fuente de inspiración para la obtención de nuevos medicamentos en Anonáceas, Plantas antiguas, estudios recientes.
  González-Esquinca, A. R., Luna-Cazáres, L. M., Gutiérrez-Jiménez, J., Schlie-Guzmán, M. A. y Vidal-López, D. G. Eds., Universidad de Ciencias y Artes de Chiapas, México, 2010. ISBN: 978-607-7510-91-8
 
  - Sáez, A., Robledo, S., Rojano, B., Cortes, D. y Sáez, J.
  Actividad leishmanicida y antioxidante de compuestos hemisintéticos de Duguetia colombiana Maas (Annonaceae) en Anonáceas, Plantas antiguas, estudios recientes.
  González-Esquinca, A. R., Luna-Cazáres, L. M., Gutiérrez-Jiménez, J., Schlie-Guzmán, M. A. y Vidal-López, D. G. Eds., Universidad de Ciencias y Artes de Chiapas, México, 2010. ISBN: 978-607-7510-91-8 
 
  - Cabedo, N., Berenguer, I., Figadère, B. y Cortes, D.
  "An overview on benzylisoquinoline derivatives with dopaminergic and serotonergic activities"
  Current Medicinal Chemistry 2009 16, 2441-2467. 
 
  - Cortes, D.
  "Farmacoquímica Natural"
  Ed. Moliner 40, Burjassot 2007. ISBN: 978-84-934871-4-0
 
  - Bermejo, A., Figadère, B., Zafra-Polo, M. C., Barrachina, I., Estornell, E. y Cortes, D.
  “Acetogenins from Annonaceae: Recent Progress in Isolation, Synthesis and Mechanisms of Action”.
  Natural Product Reports 2005, 22, 269-303.
 
  - Cortes, D., Andreu, I., Bermejo, A. y Zafra-Polo, M. C.
  "Los Principios Activos de las Plantas", en "Fitoterapia. Vademécum de Prescripción", 4ª ed., Vanaclocha, B. y Cañigueral, S. Eds., Masson, Barcelona 2003, pags 29-48.
 
 
 
Almudena, Diego, Nuria, Javier, Abraham et Laura
(Laboratoire Burjassot – Février 2012)